We’re Here to Help
Complete the following fields with your information, as well as a short, detailed description of your request and a NAGASE Specialist will be in touch with you shortly.
Arcofeliz ™
AL series: Low-Endotoxin Sodium Alginate
Arcofeliz™ AL series is a high-performance, low-endotoxin sodium alginate developed by Nagase ChemteX. Derived from premium natural brown algae, this linear polysaccharide is engineered for high-end bioscientific applications where biological safety and structural precision are paramount.
Manufacturer:
Nagase ChemteX CorporationChemical Name:
Sodium Alginate (Low Endotoxin Grade)
Applications & Uses:
Medical Devices & Biomaterials:- Advanced wound dressings with high water-retention gel layers.
- Drug Delivery Systems (DDS) as a carrier for controlled drug release.
- Physical adhesion barriers for post-surgical recovery.
- Scaffolds for 3D cell culture.
- High-purity bio-ink for 3D bioprinting.
- Cell and tissue encapsulation for immunoselection.
- High-moisturizing serums and facial masks with superior adhesion.
- Viscosity adjustment and protective film formation in hair care products.
Benefits:
- Minimized Biological Risk: Ultra-low endotoxin levels prevent unintended cellular activation and inflammatory responses.
- Exceptional Biocompatibility: Safely interacts with sensitive biological tissues and cells.
- Highly Customizable: Wide range of viscosities and M/G ratios to achieve the exact gel strength and elasticity required.
- Premium Sensory Profile: Provides a smooth, non-sticky, and non-drip texture (pseudoplastic behavior).
Performance Attributes:
| Type | Product | Grade (1% viscosity) | Specifications | |
| Standard (M/G≒1.0) | Arcofeliz™ AL-ST5 Arcofeliz™ AL-ST20 Arcofeliz™ AL-ST200 Arcofeliz™ AL-ST400 Arcofeliz™ AL-ST600 Arcofeliz™ AL-ST1000 | <10mPa·s 10 - 50mPa·s 100 - 300mPa·s 300 - 500mPa·s 500 - 700mPa·s 800 - 1,200mPa·s | Viscosoty Loss on drying Endotoxin Level Bioburden | Grade-specific ≤15% ≤30EU/g ≤100CFU/g |
| G Rich (M/G≤0.8) | Arcofeliz™ AL-HG5 Arcofeliz™ AL-HG20 Arcofeliz™ AL-HG200 Arcofeliz™ AL-HG400 Arcofeliz™ AL-HG600 Arcofeliz™ AL-HG1000 | < 10mPa·s 10 - 50mPa·s 100 - 300mPa·s 300 - 500mPa·s 500 - 700mPa·s 800 - 1,200mPa·s | Viscosoty Loss on drying Endotoxin Level Bioburden | Grade-specific ≤15% ≤30EU/g ≤100CFU/g |
| M rich (M/G≥1.5) | Arcofeliz™ AL-HM5 Arcofeliz™ AL-HM20 Arcofeliz™ AL-HM200 Arcofeliz™ AL-HM400 Arcofeliz™ AL-HM600 Arcofeliz™ AL-HM1000 | < 10mPa·s 10 - 50mPa·s 100 - 300mPa·s 300 - 500mPa·s 500 - 700mPa·s 800 - 1,200mPa·s | Viscosoty Loss on drying Endotoxin Level Bioburden | Grade-specific ≤15% ≤30EU/g ≤100CFU/g |
Approvals & Certifications:
ISO9001Physical Properties:
| Appearance: | Natural polysaccharide derived from brown algae. |
|---|---|
| Solubility: | Highly water-soluble, forming viscous solutions. |
| Viscosity: | Available in a wide range from 1 to 1,200 mPa·s. |
| Rheology: | Exhibits pseudoplastic (shear-thinning) behavior. |
| Structural Recovery: | Rapidly regains viscosity after shear stress is removed. |
Chemical Properties:
| Structure: | Linear polymer of Mannuronic acid (M) and Guluronic acid (G). |
|---|---|
| Purity: | Ultra-low endotoxin (≦10 or ≦30 EU/g) and low bioburden (≦100 CFU/g). |
| Reactivity: | Forms hydrogels instantly through cross-linking with divalent ions (e.g., Ca^{2+}). |
| Biocompatibility: | Low pro-inflammatory cytokine secretion (TNF-α, IL-6). |
Mechanical Properties:
| Tunable Texture: | Physical properties are adjustable via the M/G ratio. |
|---|---|
| Rigidity: | G-rich grades (M/G ≦ 0.8) offer high thermal stability and gel strength. |
| Elasticity: | M-rich grades (M/G ≧ 1.5) provide superior elasticity and hydration. |
| Workability: | High concentration solutions remain easy to pump and filter. |
Related Products
Low-Endotoxin Sodium Alginate
Arcofeliz ™ AL Series is a low-endotoxin sodium alginate produced by purification with a newly developed endotoxin removal materials.
Learn More
Low-Endotoxin Pullulan
Arcofeliz ™ PU-10 is a low-endotoxin pullulan produced by purification with a newly developed endotoxin removal materials.
Learn More
Low-Endotoxin Gelatin
Arcofeliz ™ GE Series is a low-endotoxin gelatin produced by purification with a newly developed endotoxin removal materials.
Learn More
Low-Endotoxin Enzyme
Arcofeliz ™ EN Series is a low-endotoxin enzyme produced by purification with a newly developed endotoxin removal materials.
Learn More
Low-Endotoxin Xanthan Gum
Arcofeliz ™ XA Series is a low-endotoxin xanthan gum produced by purification with a newly developed endotoxin removal materials.
Learn More
Low-Endotoxin Collagen Peptide
Arcofeliz ™ CP Series is a low-endotoxin collagen peptide produced by purification with a newly developed endotoxin removal materials.
Learn More
Endotoxin Feasibility Study Service
Tailored endotoxin removal service for medical biomaterials using Nagase ChemteX technology.
Learn MoreRelated Resources
Endotoxin Removal Technology
This article clearly explains what endotoxins are, their potential risks, the importance of endotoxin removal, and representative removal methods. It also introduces Nagase ChemteX’s endotoxin removal technology, which is applicable to high-viscosity materials used in raw materials for medical and biomedical applications.
Learn More
Endotoxin Control in Sodium Alginate
This article explains the origins of endotoxins in sodium alginate, why low-endotoxin grades are required, common endotoxin removal methods and their limitations, and the technological features developed by Nagase ChemteX.
Learn More
Solving the Challenge of Removing Endotoxins
Learn how NAGASE helps life science-related companies such as medical devices, pharmaceutical companies, and regenerative medicine by offering low-endotoxin material solutions and fully customized endotoxin studies.
Learn More
Endotoxin Control in Xanthan Gum
Explore the challenges of endotoxin (LPS) removal in xanthan gum. Learn about the limitations of conventional methods and Nagase ChemteX’s proprietary low-endotoxin solutions for pharma and biotech.
Learn More
Endotoxin Control in Gelatin and Collagen Peptides
Explore the technical hurdles of endotoxin (LPS) removal in gelatin. Learn how Nagase ChemteX’s proprietary ligand-specific adsorption overcomes the limitations of UF and ion-exchange to provide ultra-high purity materials for pharma and regenerative medicine.
Learn More