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Arcofeliz ™
PU-10: Low-Endotoxin Pullulan
Arcofeliz™ PU series is a high-performance biomaterial manufactured by Nagase ChemteX. It is a natural water-soluble polysaccharide produced from starch through the fermentation of the yeast-like fungus Aureobasidium pullulans. Its linear structure, consisting of maltotriose units connected by unique glycosidic bonds (α-1,4 and α-1,6), provides a highly flexible yet stable molecular arrangement.
Manufacturer:
Nagase ChemteX CorporationChemical Name:
Pullulan (Low Endotoxin Grade)
Product Applications & Uses:
- Regenerative Medicine & Cell Culture: Acts as a high-purity matrix that ensures a "silent" environment, preventing unintended macrophage activation in sensitive applications.
- Edible Films & Capsules: The premier choice for creating dense, oxygen-impermeable barriers due to its linear and flexible nature.
- Medical Coatings: Utilized for high-clarity coatings that require exceptional stability and compatibility with other hydrocolloids.
- Personal Care: Offers a smooth, non-sticky mouthfeel and excellent lubricity in oral care or topical formulations.
Benefits:
- Ultra-High Solubility: Dissolves rapidly and completely in cold water without the need for heating.
- Exceptional Film-Forming Ability: Forms clear, transparent, and oxygen-impermeable films that align closely during drying.
- Broad Compatibility: As a non-ionic polysaccharide, it remains stable across a wide pH range and in the presence of various salts.
- Biological Safety: Demonstrated significantly lower pro-inflammatory cytokine secretion (TNF-α, IL-6) compared to standard pharmacopoeia grades.
Performance Attributes:
| Product | Specifications | |
| Arcofeliz™ PU-10 | Japanese Pharmacopoeia | Reference |
| Endotoxin Level | ≤10 EU/g | |
Approvals & Certifications:
- Pharmacopoeia Reference: Arcofeliz™ PU series is developed with reference to Japanese Pharmacopoeia standards.
Brand Description:
Arcofeliz™ PU series represents the pinnacle of Nagase ChemteX’s expertise in fermentation and purification technology. By delivering a pullulan with ultra-low endotoxin levels and superior film-forming properties, the Arcofeliz™ PU series provides the reliability and safety required for the most advanced applications in healthcare and biotechnology.
Physical Properties:
| Appearance: | Natural water-soluble polysaccharide. |
|---|---|
| Solubility: | Exhibits superior cold-water solubility, dissolving rapidly and completely without heating. |
| Rheology: | Features Newtonian-like flow at low concentrations, transitioning to mild pseudoplasticity at higher concentrations. |
| Visual Clarity: | Forms perfectly crystal-clear and transparent solutions even at high concentrations. |
| Sensory Profile: | Provides a smooth, non-sticky mouthfeel and excellent lubricity in solution. |
Chemical Properties:
| Structure: | A linear polymer of maltotriose units connected by alternating α-1,4 and α-1,6 glycosidic bonds. |
|---|---|
| Purity: | Strictly controlled ultra-low endotoxin levels (≦10 EU/g). |
| Stability: | Non-ionic nature ensures stability in the presence of various salts and across a broad pH range. |
| Biocompatibility: | Demonstrates significantly lower pro-inflammatory cytokine secretion (TNF-α, IL-6) compared to standard grades. |
Mechanical Properties:
| Film-Forming Excellence: | Linear and flexible molecules align during drying to form a dense, oxygen-impermeable barrier. |
|---|---|
| Structural Flexibility: | The unique α-1,6 linkages provide a flexible, coil-like conformation that prevents insoluble aggregation. |
| Compatibility: | Highly compatible for blending with other hydrocolloids due to its non-ionic character. |
| Workability: | Low viscosity allows for easy de-aeration (removal of bubbles), which is essential for producing high-quality films and capsules. |
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