Coagulation & Fibrinolysis
A globally recognized portfolio of highly purified serine protease substrates, specific inhibitors, and diagnostic reagents optimized for hemostasis testing, coagulation assays, and pharmaceutical quality control. Features highly selective peptide chemistries (Pefachrome and Pefafluor) and robust inhibitors (Pefabloc) to support precise kinetic determinations.
Applications & Uses:
- Chromogenic and fluorogenic assays for serine protease activity in coagulation and fibrinolysis
- In-process and quality control of pharmaceutical preparations
- Inhibition of unwanted proteolytic activities during diagnostic processing
- LAL endotoxin determination and C1-esterase diagnostic assays
Benefits:
- Highly selective peptide chemistries: Synthesized chromogenic (Pefachrome) and fluorogenic (Pefafluor) substrates target specific coagulation cascade enzymes (such as Thrombin, Factor Xa, and Plasmin) with high precision
- Extensive substrate dynamic range: Features calibrated Km and Vmax kinetics to guarantee swift and accurate color development or fluorescence
- Highly stable inhibitors: Specific inhibitors protect diagnostic systems from proteolytic degradation and prolong reagent shelf life
- Animal-free stabilizer options: Stabilizer optimizes enzyme stability and heat resistance without risk of bovine-derived pathogens
Performance Attributes:
- Demonstrate precise substrate conversion kinetics with highly reproducible Km values.
- Provide complete protease inhibition with high chemical stability under analytical conditions.
- Support rapid and highly linear absorbance changes at 405 nm for chromogenic substrates.
Sub Category:
EnzymesPhysical Properties:
| Appearance: | White to off-white lyophilized solid, or clear liquid |
|---|---|
| Solubility: | Highly soluble in water and physiological buffers |
Chemical Properties:
| Purity: | Certified diagnostic-grade highly purified proteins or synthetic peptide complexes |
|---|---|
| Viral safety: | Free of biological active infectious contaminants |
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