Monoclonal Antibodies
A comprehensive portfolio of high-purity, clinical-grade monoclonal antibodies (mAbs) designed for in vitro diagnostic (IVD) assay development. Developed via hybridoma technology and recombinant expression systems, these antibodies are validated across diagnostic platforms to ensure consistent performance, clinical correlation, and batch-to-batch consistency. Optimized for diverse immunoassays, they cover diagnostic panels including cardiac markers, infectious diseases, tumor markers, and inflammatory diseases.
Applications & Uses:
- Chemiluminescent immunoassays (CLIA) and ELISA
- Lateral flow assays (rapid tests) using colloidal gold or fluorescent nanoparticles
- Latex particle-enhanced immunoturbidimetric assays (PETIA)
- Active capture and detection pairs in sandwich immunoassay systems
Diagnostic Target Panels (mAbs):
- Cardiac Markers: Troponin I, Troponin T, NT-proBNP, D-Dimer, Myoglobin, CK-MB
- Infectious Diseases: Influenza A/B, RSV, Adenovirus, Strep A, Malaria, Dengue
- Tumor Markers: AFP, CEA, PSA (Free and Total), PIVKA-II, CA125, CA19-9
- Inflammatory Markers: CRP, Procalcitonin (PCT), SAA, IL-6
Benefits:
- High lot-to-lot consistency: Large-scale production capacity ensuring consistent batch performance with a coefficient of variation (CV) of less than 5%.
- Proven clinical correlation: Validated against industry-standard commercial assays (e.g., troponin T correlation R-squared of 0.98 or higher; D-Dimer correlation R-squared of 0.98 or higher).
- High specificity and sensitivity: Selected matched pairs ensure minimal matrix interference and high dilution linearity without hook effects at standard clinical ranges.
Performance Attributes:
- Exhibit high affinity with an affinity constant Ka of 1 billion to 10 billion M-1 or higher.
- Provide highly specific matched antibody pairs for sandwich immunoassay.
- Ensure reliable sensitivity and low cross-reactivity across targeted clinical panels.
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Sub Category:
Antibodies/AntigensPhysical Properties:
| Appearance: | Clear, colorless to slightly yellow liquid |
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| Solubility: | Fully miscible in aqueous buffers |
| Molecular Weight: | Approximately 150,000 Daltons (IgG) |
Chemical Properties:
| Purity: | Equal to or greater than 95% by SDS-PAGE |
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| Buffer formulation: | Supplied in standard PBS (pH 7.2 to 7.4), available as azide-free or with 0.1% sodium azide depending on the grade |
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