IgG
A next-generation portfolio of highly purified biological-grade bulk immunoglobulins (Bulk IgG's) designed specifically as active heterophilic blocking agents in in vitro diagnostic (IVD) test kits. Processed via advanced Protein A or Protein G affinity chromatography, these immunoglobulins successfully neutralize and eliminate non-specific interference including HAMA (Human Anti-Mouse Antibodies) and Rheumatoid Factors (RF), preventing false-positive results and maximizing assay diagnostic specificity.
Applications & Uses:
- Active heterophilic blocking agent in sandwich CLIA, ELISA, and lateral flow assays to neutralize human anti-mouse antibody (HAMA) interferences
- Specific assay formulation diluent component to suppress rheumatoid factor (RF) and non-specific immunochemical binding
- Native reference control standards, calibrator formulations, and assay validation targets in clinical testing platforms
Benefits:
- High HAMA neutralization capacity: Meticulously refined through solid-phase affinity chromatography, providing targeted blocking of heterophilic antibodies and avoiding non-specific bridge agglutination
- Ultra-high purity profile: Certified equal to or greater than 95% pure active immunoglobulin G determined by SDS-PAGE analysis, completely eliminating baseline turbidity and micro-plate background variations
- Multiple species availability: Broad range of host species (including Mouse, Goat, Rabbit, Sheep, and Rat IgG) provided in consistent high bulk scales (ranging from grams to kilograms)
- Stable liquid or dry formats: Available as high-concentration stable liquids (8 to 12 mg/mL in physiological saline) or highly stable lyophilized powders designed for instant, clear reconstitution in diagnostic buffers
Performance Attributes:
- Exhibits single-band high purity of 95% or more under standard SDS-PAGE electrophoresis analysis.
- Achieves 98% or greater neutralization efficiency of patient-derived HAMA and heterophilic antibodies in clinical specimens.
- Dissolves instantly and completely without particulate residues, maintaining stable pH baseline buffer conditions.
Sub Category:
Animal DerivedPhysical Properties:
| Appearance: | Clear colorless to slightly yellow liquid (or white lyophilized powder) |
|---|---|
| Solubility: | Soluble and highly miscible in physiological water-based buffers |
| Molecular weight: | Approximately 150,000 Daltons |
Chemical Properties:
| Purity: | Equal to or greater than 95% (SDS-PAGE) |
|---|---|
| Buffer: | Supplied in physiological phosphate buffered saline (PBS, pH 7.2 to 7.4) |
| Formulation options: | Available in azide-free or azide-containing (0.1%) formulations |
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