Streamlined Peptide and Oligo Manufacturing in Downstream Processes
August 28, 2025
This presentation, delivered at TIDES US 2025, offered highly insightful technical perspectives on optimization strategies in peptide and oligonucleotide downstream processing. The session highlighted advanced approaches such as continuous chromatography and mixer-type lyophilization, providing valuable learnings for streamlining manufacturing workflows and enhancing process efficiency.
Presentation Title:
Technical Application of Continuous Chromatography and Mixer-Type Lyophilization in Peptide and Oligonucleotide Downstream Processes
Presentation Abstract:
To accelerate the development of peptides and oligonucleotides as pharmaceuticals, it is necessary to develop technologies that overturn traditional approaches and overcome cost and quality challenges in all manufacturing processes, including synthesis, purification, and lyophilization. In this presentation, we will introduce examples of scale-up purification using a continuous chromatography system and additional data on the mixer-type lyophilizer.