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Nagase ChemteX has succeeded in developing a new esterase
SNSM-87 with DNA technology, which boasts an ability to withstand
twice as much heat compare to existing chiral compounds. The
new product will form the core of a market expansion drive
by Nagase ChemteX, conjunction with pharmaceutical manufacturers,
universities and research institutes.
SNSM-87 is a purified enzyme produced by the expression of
heat-stable esterase genes (originally derived from Klebsiella
oxytoca) in the industrial host E-coli (JM 105 stock). Its
main feature is in its significantly improved heat stability
with verifiable activity at close to 80 degrees C, whereas
conventional natural enzymes are inactive at temperatures
above the 30-40 degrees C range. The specific application
of this esterase is in the stereo selective hydrolysis of
esters. Especially so in recent years, successful commercialization
of pharmaceutical-use esterase is considered rare.
The commercialization of SNSM-87 will not be focused on selling
the item alone, instead, on joining forces with pharmaceutical
manufacturers, universities and research institutes, in search
for an optimum use for SNSM-87's superior heat stability.
SNSM-87 received official confirmation for having complied
with METI's "Recombinant DNA Technology Industrialization
Guidelines" in October 2001. This being the second official
compliance acknowledgement from METI to Nagase, Nagase Biochemical
has received the first.
(Source: The Chemical Daily)
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